Respiratory muscle function and free radicals: from cell to COPD
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چکیده
منابع مشابه
Respiratory muscle function and free radicals: from cell to COPD.
Respiratory muscle dysfunction in chronic obstructive pulmonary disease (COPD) Dysfunction of the respiratory muscles, especially the diaphragm, is known to occur in patients with severe chronic obstructive pulmonary disease (COPD). Weakness of the diaphragm is part of a generalised process involving all (respiratory and peripheral) skeletal muscles. Causative factors for respiratory muscle dys...
متن کاملOccasional review Respiratory muscle function and free radicals: from cell to COPD
Respiratory muscle dysfunction in chronic obstructive pulmonary disease (COPD) Dysfunction of the respiratory muscles, especially the diaphragm, is known to occur in patients with severe chronic obstructive pulmonary disease (COPD). Weakness of the diaphragm is part of a generalised process involving all (respiratory and peripheral) skeletal muscles. Causative factors for respiratory muscle dys...
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At high concentrations, free radicals and radical-derived, nonradical reactive species are hazardous for living organisms and damage all major cellular constituents. At moderate concentrations, however, nitric oxide (NO), superoxide anion, and related reactive oxygen species (ROS) play an important role as regulatory mediators in signaling processes. Many of the ROS-mediated responses actually ...
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The first suggestion that physical exercise results in free radical-mediated damage appeared in 1978, and since that time the sources of oxidant production during exercise continue to be debated. Many researchers focused on the damaging effects of oxidants in muscle (oxidative damage of proteins and lipids), but the examination of cell-signaling effects of free radicals on muscle activity becam...
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ژورنال
عنوان ژورنال: Thorax
سال: 2000
ISSN: 0040-6376
DOI: 10.1136/thorax.55.8.704